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Name of Image: Turnip Yellow Mosaic Virus Structure
MIX #: 0004368
NIX #: 0004368 MSFC-0004368
Date of Image: 2000-05-01
Category: Microgravity

Full Description: The bumpy exterior of the turnip yellow mosaic virus (TYMV) protein coat, or capsid, was defined in detail by Dr. Alexander McPherson of the University of California, Irvin using protein crystallized in space for analysis on Earth. TYMV is an icosahedral virus constructed from 180 copies of the same protein arranged into 12 clusters of five proteins (pentamers), and 20 clusters of six proteins (hexamers). The final TYMV structure led to the enexpected hypothesis that the virus release its RNA by essentially chemical-mechanical means. Most viruses have farly flat coats, but in TYMV, the fold in each protein, called the jellyroll, is clustered at the points where the protein pentamers and hexamers join. The jellyrolls are almost standing on end, producing a bumpy surface with knobs at all of the pentamers and hexamers. At the inside surface of the pentamers is a void that is not present at the hexamers. The coating had been seen in early studies of TYMV, but McPhereson's atomic structure shows much more detail. The inside surface is strikingly, and unexpectedly, different than the outside. While the pentamers contain a central viod on the inside, the hexameric units contain peptides liked to each other, forming a ring or, more accurately, rings to fill the voild. Credit: Dr. Alexander McPherson, University of California, Irvine.
(MRPO) MRD/SPD Discipline(s): Biotechnology
(MRPO) Subject Type: Science
Keywords: Turnip Yellow Mosaic Virus, TYMV, Protein, McPherson
MSFC Negative Number: 0004368
Reference Number: MSFC-75-SA-4105-2C
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